Chemical Structure
(Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol.)
Rottlerin Small Molecule
Rottlerin
Purity
>=98%
Synonyms
Rottlerin; Autophagy inducer; 3'-[(8-Cinnamoyl-5; 7-dihydroxy-2; 2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2'; 4'; 6'-trihydroxy-5'-methylacetophenone; Rottlerin small molecule
Host
Synthetic
Purity/Purification
>=98%
Form/Format
Orange to brown solid.
Solubility
Soluble to 2 mM in ethanol and to 20 mM in DMSO.
CAS Number
82-08-6
Molecular Formula
C30H28O8
SMILES
C1=CC=CC=C1/C=C/C(C2=C(C(=C(C3=C2OC(C)(C)C=C3)O)CC4=C(C(=C(C(=C4O)C(C)=O)O)C)O)O)=O
InChI
1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChI Key
DEZFNHCVIZBHBI-ZHACJKMWSA-N
PubChem CID
5281847
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol.)
Chemical Structure
(Chemical structure of Rottlerin (SIH-394), a Autophagy inducer. CAS #: 82-08-6. Molecular Formula: C30H28O8. Molecular Weight: 516.55 g/mol.)
Related Product Information for Rottlerin small molecule
Rottlerin has been shown to inhibit protein kinase C as well as CAM kinase III. It is also a potent activator of many K+ channels which are Ca2+-activated. Studies have illustrated Rottlerin to act as a mitochondrial uncoupler which depolarizes membrane potential. Lastly, Rottlerin can induce autophagy by inhibition of mTORC1 signalling.
Product Categories/Family for Rottlerin small molecule
References
1. Gschwendt M. et al. (1994) Biochem Biophys Res Commun. 199(1): 93-8. 2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66. 3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92. 4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.
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Product Notes
The Rottlerin (Catalog #AAA808098) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rottlerin, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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