Rabbit anti-Human, Mouse GTPBP4 Polyclonal Antibody | anti-GTPBP4 antibody

GTPBP4 Rabbit Polyclonal

Cat. Num. AAA769954

• Gene Names: GTPBP4; NGB; CRFG; NOG1
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GTPBP4; Polyclonal Antibody; GTPBP4 Rabbit Polyclonal; anti-GTPBP4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 632

• Applicable Applications for anti-GTPBP4 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: GTP binding protein 4
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human cervical cancer using MBS769954 (GTPBP4 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS769954 (GTPBP4 antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 21707262
• NCBI GeneID: 23560
• Molecular Weight: 60,051 Da
• NCBI Official Full Name: GTPBP4 protein, partial
• NCBI Official Synonym Full Names: GTP binding protein 4
• NCBI Official Symbol: GTPBP4
• NCBI Official Synonym Symbols: NGB; CRFG; NOG1
• NCBI Protein Information: nucleolar GTP-binding protein 1
• UniProt Protein Name: Nucleolar GTP-binding protein 1
• UniProt Gene Name: GTPBP4
• UniProt Synonym Gene Names: CRFG; NOG1
• UniProt Entry Name: NOG1_HUMAN

NCBI Description

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Uniprot Description

GTPBP4: Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the GTP1/OBG family. NOG subfamily.

Protein type: RNA-binding; Nucleolus; Ribosomal

Chromosomal Location of Human Ortholog: 10p15-p14

Cellular Component: cytoplasm; Golgi apparatus; membrane; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm

Molecular Function: GTP binding; GTPase activity; protein binding

Biological Process: negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of collagen binding; negative regulation of DNA replication; negative regulation of protein ubiquitination; osteoblast differentiation; protein stabilization; regulation of cyclin-dependent protein kinase activity; ribosome biogenesis and assembly