Rabbit GMPS Polyclonal Antibody | anti-GMPS antibody

GMPS Rabbit Polyclonal

Cat. Num. AAA769761

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GMPS; Polyclonal Antibody; GMPS Rabbit Polyclonal; anti-GMPS antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 693

• Applicable Applications for anti-GMPS antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Guanine monphosphate synthetase
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS769761 (GMPS antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 4504035
• NCBI GeneID: 8833
• NCBI Accession #: NP_003866.1
• NCBI GenBank Nucleotide #: NM_003875.2
• Molecular Weight: 65,929 Da
• NCBI Official Full Name: GMP synthase
• NCBI Official Synonym Full Names: guanine monophosphate synthase
• NCBI Official Symbol: GMPS
• NCBI Protein Information: GMP synthase [glutamine-hydrolyzing]
• UniProt Protein Name: GMP synthase [glutamine-hydrolyzing]
• UniProt Gene Name: GMPS
• UniProt Entry Name: GUAA_HUMAN

NCBI Description

In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]

Uniprot Description

GMPS: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with MLL.

Protein type: Ligase; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine; EC 6.3.5.2

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: cytoplasm; cytosol

Molecular Function: ATP binding; GMP synthase (glutamine-hydrolyzing) activity; GMP synthase activity; pyrophosphatase activity

Biological Process: glutamine metabolic process; GMP biosynthetic process; purine base biosynthetic process; purine ribonucleoside monophosphate biosynthetic process

Disease: Leukemia, Acute Myeloid