Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS767803 (CDT1 antibody) at dilution of 1:500)
Rabbit anti-Human CDT1 Polyclonal Antibody | anti-CDT1 antibody
CDT1 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS767803 (CDT1 antibody) at dilution of 1:500)
Western Blot (WB)
(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS767803 (CDT1 antibody) at dilution of 1:500)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]
Uniprot Description
CDT1: an essential licensing protein for DNA replication. Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Elevated in all human tumor cell lines analyzed. May function as an oncogene in mammals. Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.
Protein type: DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: cytosol; nucleoplasm; nucleus
Molecular Function: DNA binding; protein binding
Biological Process: DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; regulation of DNA replication during S phase; regulation of DNA replication initiation
Disease: Meier-gorlin Syndrome 4
Research Articles on CDT1
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Product Notes
The CDT1 cdt1 (Catalog #AAA767803) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CDT1 Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CDT1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the CDT1 cdt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CDT1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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