Rabbit CCAR2 Polyclonal Antibody | anti-CCAR2 antibody

CCAR2 Rabbit Polyclonal

Cat. Num. AAA767570

• Gene Names: CCAR2; DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CCAR2; Polyclonal Antibody; CCAR2 Rabbit Polyclonal; anti-CCAR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 923

• Applicable Applications for anti-CCAR2 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
• Immunogen: KIAA1967
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse liver using MBS767570 (CCAR2 Antibody) at dilution of 1:100)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS767570 (CCAR2 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 24432106
• NCBI GeneID: 57805
• NCBI Accession #: NP_066997.3
• NCBI GenBank Nucleotide #: NM_021174.5
• Molecular Weight: 103,143 Da
• NCBI Official Full Name: cell cycle and apoptosis regulator protein 2
• NCBI Official Synonym Full Names: cell cycle and apoptosis regulator 2
• NCBI Official Symbol: CCAR2
• NCBI Official Synonym Symbols: DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
• NCBI Protein Information: cell cycle and apoptosis regulator protein 2
• UniProt Protein Name: Cell cycle and apoptosis regulator protein 2
• Protein Family: Cell cycle and apoptosis regulator protein
• UniProt Gene Name: CCAR2
• UniProt Synonym Gene Names: DBC1; KIAA1967; DBC-1; DBC.1
• UniProt Entry Name: CCAR2_HUMAN

Uniprot Description

DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; RNA-binding; Tumor suppressor; Mitochondrial; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cytoplasm; mitochondrial matrix; nuclear chromatin; nucleoplasm; nucleus; spliceosome

Molecular Function: enzyme binding; enzyme inhibitor activity; protein binding

Biological Process: cell cycle; mitochondrial fragmentation during apoptosis; mRNA processing; negative regulation of catalytic activity; negative regulation of cell growth; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of circadian rhythm; regulation of protein stability; regulation of RNA elongation; response to DNA damage stimulus; response to UV; rhythmic process; RNA splicing; transcription, DNA-dependent; Wnt receptor signaling pathway