Rabbit TAB3 Polyclonal Antibody | anti-TAB3 antibody

anti-TAB3 antibody

Cat. Num. AAA7611910

• Gene Names: TAB3; NAP1; MAP3K7IP3
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Synonyms: TAB3; Polyclonal Antibody; anti-TAB3 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;NF-kappa-B-activating protein 1; TAK1-binding protein 3; MAP3K7IP3

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Form/Format: Liquid. PBS with 0.02% sodium azide and 50% glycerol pH7.3

• Applicable Applications for anti-TAB3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:100
• Immunogen: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• Preparation and Storage: Store at -20 degree C for 12 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat kidney tissue slide using MBS7611910(TAB3 Antibody) at dilution of 1:50)

Immunofluorescence (IF)

(Immunofluorescent analysis of A431 cells using MBS7611910 (TAB3 antibody) at dilution of 1:50.)

Western Blot (WB)

(293T cells were subjected to SDS PAGE followed by western blot with MBS7611910(TAB3 Antibody) at dilution of 1:1000)

Related Product Information for anti-TAB3 antibody

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Product Categories/Family for anti-TAB3 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 98991767
• NCBI GeneID: 257397
• NCBI Accession #: NP_690000
• NCBI GenBank Nucleotide #: NM_152787.3
• UniProt Accession #: Q8N5C8; Q6VQR0; A6NDD9
• Molecular Weight: 75,599 Da
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1/MAP3K7 binding protein 3
• NCBI Official Symbol: TAB3
• NCBI Official Synonym Symbols: NAP1; MAP3K7IP3
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAB-3; TAK1-binding protein 3; NFkB activating protein 1; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interactin
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• Protein Family: TGF-beta-activated kinase 1 and MAP3K7-binding protein
• UniProt Gene Name: TAB3
• UniProt Synonym Gene Names: MAP3K7IP3; TAB-3
• UniProt Entry Name: TAB3_HUMAN

NCBI Description

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; cytosol

Molecular Function: protein binding; zinc ion binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway