Rabbit anti-Human TAB3 Polyclonal Antibody | anti-TAB3 antibody

TAB3 Antibody

Cat. Num. AAA150688

• Gene Names: TAB3; NAP1; MAP3K7IP3
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: TAB3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TAB3; Polyclonal Antibody; TAB3 Antibody; NAP1; MAP3K7IP3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; TAB-3; TGF-beta activated kinase 1/MAP3K7 binding protein 3; anti-TAB3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins.
• Purity/Purification: TAB3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 712

• Applicable Applications for anti-TAB3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.
• Buffer: TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TAB3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Immunohistochemistry (IHC)

(Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 μg/mL.)

Related Product Information for anti-TAB3 antibody

TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

NCBI and Uniprot Product Information

• NCBI GI #: 98991767
• NCBI GeneID: 257397
• NCBI Accession #: NP_690000
• NCBI GenBank Nucleotide #: NM_152787.3
• UniProt Accession #: Q8N5C8; Q6VQR0; A6NDD9
• Molecular Weight: 75,599 Da
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1/MAP3K7 binding protein 3
• NCBI Official Symbol: TAB3
• NCBI Official Synonym Symbols: NAP1; MAP3K7IP3
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TAB-3; TAK1-binding protein 3; NFkB activating protein 1; NF-kappa-B-activating protein 1; TGF-beta-activated kinase 1-binding protein 3; mitogen-activated protein kinase kinase kinase 7 interacting protein 3
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
• Protein Family: TGF-beta-activated kinase 1 and MAP3K7-binding protein
• UniProt Gene Name: TAB3
• UniProt Synonym Gene Names: MAP3K7IP3; TAB-3
• UniProt Entry Name: TAB3_HUMAN

NCBI Description

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; cytosol

Molecular Function: protein binding; zinc ion binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway