Rabbit anti-Human TAF1C Polyclonal Antibody | anti-TAF1C antibody

TAF1C Rabbit Polyclonal

Cat. Num. AAA7604715

• Gene Names: TAF1C; SL1; TAFI95; TAFI110; MGC:39976
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TAF1C; Polyclonal Antibody; TAF1C Rabbit Polyclonal; anti-TAF1C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 392

• Applicable Applications for anti-TAF1C antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using MBS7604715 (TAF1C Antibody) at dilution of 1:100)

Western Blot (WB)

(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS7604715 (TAF1C Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 341926289
• NCBI GeneID: 9013
• NCBI Accession #: NP_001230089.1
• NCBI GenBank Nucleotide #: NM_001243160.1
• Molecular Weight: 92,284 Da
• NCBI Official Full Name: TATA box-binding protein-associated factor RNA polymerase I subunit C isoform 6
• NCBI Official Synonym Full Names: TATA-box binding protein associated factor, RNA polymerase I subunit C
• NCBI Official Symbol: TAF1C
• NCBI Official Synonym Symbols: SL1; TAFI95; TAFI110; MGC:39976
• NCBI Protein Information: TATA box-binding protein-associated factor RNA polymerase I subunit C
• UniProt Protein Name: TATA box-binding protein-associated factor RNA polymerase I subunit C
• Protein Family: TATA box-binding protein-associated factor
• UniProt Gene Name: TAF1C
• UniProt Synonym Gene Names: TAFI110; TBP-associated factor 1C
• UniProt Entry Name: TAF1C_HUMAN

NCBI Description

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Uniprot Description

TAF1C: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription initiation complex

Chromosomal Location of Human Ortholog: 16q24

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; RNA polymerase I transcription factor complex

Molecular Function: protein binding

Biological Process: positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; transcription from RNA polymerase I promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter