NCBI Description
This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy. [provided by RefSeq, Oct 2010]
Uniprot Description
SDCCAG8: Plays a role in the establishment of cell polarity and epithelial lumen formation. May play a role in ciliogenesis. Defects in SDCCAG8 are the cause of Senior-Loken syndrome type 7 (SLSN7). SLSN7 is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: centriole; centrosome; cytosol; intercellular junction
Molecular Function: protein binding
Biological Process: centrosome organization and biogenesis; establishment of cell polarity; G2/M transition of mitotic cell cycle; lumen formation; neuron migration
Disease: Bardet-biedl Syndrome 1; Bardet-biedl Syndrome 16; Senior-loken Syndrome 7
Product Notes
The SDCCAG8 sdccag8 (Catalog #
AAA7603899) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SDCCAG8 Rabbit Polyclonal reacts with Human, Mouse, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's SDCCAG8 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunofluorescence (IF). Researchers should empirically determine the suitability of the SDCCAG8 sdccag8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"SDCCAG8, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
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responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
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