Rabbit anti-Human EHBP1 Polyclonal Antibody | anti-EHBP1 antibody

EHBP1 antibody

Cat. Num. AAA9414087

• Gene Names: EHBP1; HPC12; NACSIN
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: EHBP1; Polyclonal Antibody; EHBP1 antibody; anti-EHBP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
• Sequence Length: 1231

• Applicable Applications for anti-EHBP1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western blotting: 1:500-1:3000; Immunofluorescence: 1:100-1:200
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 595 and 856 of EHBP1
• Target Name: EHBP1
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

Testing Data

(Sample (30 ug of whole cell lysate) A: H1299 5% SDS PAGE Primary antibody diluted at 1: 1000)

Immunofluorescence (IF)

(Immunofluorescence analysis of paraformaldehyde-fixed A549, using EHBP1 antibody at 1: 200 dilution.)

Product Categories/Family for anti-EHBP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 217330568
• NCBI GeneID: 23301
• NCBI Accession #: NP_056067
• NCBI GenBank Nucleotide #: NM_015252.3
• Molecular Weight: 132,322 Da
• NCBI Official Full Name: EH domain-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: EH domain binding protein 1
• NCBI Official Symbol: EHBP1
• NCBI Official Synonym Symbols: HPC12; NACSIN
• NCBI Protein Information: EH domain-binding protein 1
• UniProt Protein Name: EH domain-binding protein 1
• Protein Family: EH domain-binding protein
• UniProt Gene Name: EHBP1
• UniProt Synonym Gene Names: KIAA0903; NACSIN
• UniProt Entry Name: EHBP1_HUMAN

NCBI Description

This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Uniprot Description

EHBP1: May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. Defects in EHBP1 are a cause of susceptibility to prostate cancer hereditary type 12 (HPC12). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: cytoplasm; plasma membrane

Disease: Prostate Cancer, Hereditary, 12