Rabbit anti-Human RASGRP3 Polyclonal Antibody | anti-RASGRP3 antibody

RASGRP3 Rabbit Polyclonal

Cat. Num. AAA7603366

• Gene Names: RASGRP3; GRP3
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RASGRP3; Polyclonal Antibody; RASGRP3 Rabbit Polyclonal; anti-RASGRP3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 690

• Applicable Applications for anti-RASGRP3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: RAS guanyl releasing protein 3 (calcium and DAG-regulated)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovary tumor slide using MBS7603366 (RASGRP3 Antibody) at dilution of 1:50)

Western Blot (WB)

(RAW264.7 cells were subjected to SDS PAGE followed by western blot with MBS7603366 (RASGRP3 antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 213385270
• NCBI GeneID: 25780
• NCBI Accession #: NP_001132960.1
• NCBI GenBank Nucleotide #: NM_001139488.1
• Molecular Weight: 78,203 Da
• NCBI Official Full Name: ras guanyl-releasing protein 3 isoform 1
• NCBI Official Synonym Full Names: RAS guanyl releasing protein 3
• NCBI Official Symbol: RASGRP3
• NCBI Official Synonym Symbols: GRP3
• NCBI Protein Information: ras guanyl-releasing protein 3
• UniProt Protein Name: Ras guanyl-releasing protein 3
• Protein Family: Ras guanyl-releasing protein
• UniProt Gene Name: RASGRP3
• UniProt Synonym Gene Names: GRP3; KIAA0846
• UniProt Entry Name: GRP3_HUMAN

NCBI Description

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Uniprot Description

RASGRP3: Guanine nucleotide exchange factor (GEF) for Ras and Rap1. Belongs to the RASGRP family.

Protein type: GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 2p25.1-p24.1

Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: calcium ion binding; diacylglycerol binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; kinase binding; protein binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity; signal transducer activity

Biological Process: MAPKKK cascade; positive regulation of GTPase activity; Ras protein signal transduction; small GTPase mediated signal transduction