NCBI and Uniprot Product Information
Uniprot Description
osterix: Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. Defects in SP7 are the cause of osteogenesis imperfecta type 11 (OI11). A connective tissue disorder characterized by bone fragility, low bone mass, recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae. Belongs to the Sp1 C2H2-type zinc-finger protein family.
Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytoplasm; nucleus
Molecular Function: DEAD/H-box RNA helicase binding; DNA binding; metal ion binding
Biological Process: regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter
Disease: Osteogenesis Imperfecta, Type Xii
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Product Notes
The Rabbit OSX sp7 (Catalog #AAA752794) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA752794 ELISA Kit recognizes Rabbit OSX. It is sometimes possible for the material contained within the vial of "Osterix, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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