Guinea Pig Serine peptidase inhibitors K1 ELISA Kit | SPINK1 elisa kit
Guinea pig Serine peptidase inhibitors K1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]
Uniprot Description
SPINK1: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity
Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; regulation of acrosome reaction
Disease: Tropical Calcific Pancreatitis; Pancreatitis, Hereditary
Research Articles on SPINK1
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Product Notes
The Guinea Pig SPINK1 spink1 (Catalog #AAA7240387) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7240387 ELISA Kit recognizes Guinea Pig SPINK1. It is sometimes possible for the material contained within the vial of "Serine peptidase inhibitors K1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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