Porcine Cyclin-dependent kinase 4 inhibitor C (CDKN2C) ELISA Kit | CDKN2C elisa kit

Porcine Cyclin-dependent kinase 4 inhibitor C (CDKN2C) ELISA Kit

Cat. Num. AAA7221946

• Gene Names: CDKN2C; p18; INK4C; p18-INK4C
• Reactivity: Porcine
• Synonyms: Cyclin-dependent kinase 4 inhibitor C (CDKN2C); Porcine Cyclin-dependent kinase 4 inhibitor C (CDKN2C) ELISA Kit; CDKN2C elisa kit

• Reactivity: Porcine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for CDKN2C elisa kit

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 17981699
• NCBI GeneID: 1031
• NCBI Accession #: NP_523240.1
• NCBI GenBank Nucleotide #: NM_078626.2
• Molecular Weight: 18,127 Da
• NCBI Official Full Name: cyclin-dependent kinase 4 inhibitor C
• NCBI Official Synonym Full Names: cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
• NCBI Official Symbol: CDKN2C
• NCBI Official Synonym Symbols: p18; INK4C; p18-INK4C
• NCBI Protein Information: cyclin-dependent kinase 4 inhibitor C; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18
• UniProt Protein Name: Cyclin-dependent kinase 4 inhibitor C
• Protein Family: Cyclin-dependent kinase 4 inhibitor
• UniProt Gene Name: CDKN2C
• UniProt Synonym Gene Names: CDKN6
• UniProt Entry Name: CDN2C_HUMAN

NCBI Description

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

Protein type: Protein kinase, regulatory subunit; Cell cycle regulation; Inhibitor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding

Biological Process: negative regulation of cell proliferation; oligodendrocyte differentiation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; negative regulation of cell growth; mitotic cell cycle; cell cycle arrest; G1/S transition of mitotic cell cycle