Guinea Pig Centrosomal protein of 57 kDa (CEP57) ELISA Kit | Cep57 elisa kit
Guinea pig Centrosomal protein of 57 kDa (CEP57) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CEP57: Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2. Defects in CEP57 are the cause of mosaic variegated aneuploidy syndrome type 2 (MVA2). MVA2 is a severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. Belongs to the translokin family. 4 isoforms of the human protein are produced by alternative splicing.
Cellular Component: nucleoplasm; microtubule cytoskeleton; Golgi apparatus; centrosome; microtubule; cytoskeleton; cell; cytoplasm; intracellular; nucleus
Molecular Function: identical protein binding; gamma-tubulin binding; protein binding; fibroblast growth factor binding; protein homodimerization activity; microtubule binding
Biological Process: fibroblast growth factor receptor signaling pathway; protein import into nucleus, translocation; protein homooligomerization
Research Articles on Cep57
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Product Notes
The Guinea Pig Cep57 cep57 (Catalog #AAA7208559) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7208559 ELISA Kit recognizes Guinea Pig Cep57. It is sometimes possible for the material contained within the vial of "Centrosomal protein of 57 kDa (CEP57), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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