Lysyl Oxidase Homolog 1 (LOXL1) Recombinant Protein | LOXL1 recombinant protein
Recombinant Human Lysyl Oxidase Homolog 1 (LOXL1), Partial
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]
Uniprot Description
LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.
Protein type: Secreted; Secreted, signal peptide; Extracellular matrix; EC 1.4.3.-; Oxidoreductase
Chromosomal Location of Human Ortholog: 15q22
Cellular Component: acrosome; basement membrane; extracellular matrix; extracellular region; extracellular space
Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Biological Process: extracellular matrix organization and biogenesis; protein amino acid deamination; response to lipopolysaccharide
Disease: Exfoliation Syndrome
Research Articles on LOXL1
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Product Notes
The LOXL1 loxl1 (Catalog #AAA7115232) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 106-574aa; Partial. The amino acid sequence is listed below: VGSDTVRGQA RHPFGFGQVP DNWREVAVGD STGMARARTS VSQQRHGGSA SSVSASAFAS TYRQQPSYPQ QFPYPQAPFV SQYENYDPAS RTYDQGFVYY RPAGGGVGAG AAAVASAGVI YPYQPRARYE EYGGGEELPE YPPQGFYPAP ERPYVPPPPP PPDGLDRRYS HSLYSEGTPG FEQAYPDPGP EAAQAHGGDP RLGWYPPYAN PPPEAYGPPR ALEPPYLPVR SSDTPPPGGE RNGAQQGRLS VGSVYRPNQN GRGLPDLVPD PNYVQASTYV QRAHLYSLRC AAEEKCLAST AYAPEATDYD VRVLLRFPQR VKNQGTADFL PNRPRHTWEW HSCHQHYHSM DEFSHYDLLD AATGKKVAEG HKASFCLEDS TCDFGNLKRY ACTSHTQGLS PGCYDTYNAD IDCQWIDITD VQPGNYILKV HVNPKYIVLE SDFTNNVVRC NIHYTGRYVS ATNCKIVQS. It is sometimes possible for the material contained within the vial of "Lysyl Oxidase Homolog 1 (LOXL1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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