Western Blot (WB)
(Western BlotPositive WB detected in: HepG2 whole cell lysate, 293T whole cell lysateAll lanes: SMC5 antibody at 4.6ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 129 KDaObserved band size: 129 KDa)
Rabbit anti-Human SMC5 Polyclonal Antibody | anti-SMC5 antibody
SMC5 Antibody
Gene Names
SMC5; SMC5L1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
>95%, Protein G purified
Synonyms
SMC5; Polyclonal Antibody; SMC5 Antibody; Structural maintenance of chromosomes protein 5; SMC protein 5; SMC-5; hSMC5; KIAA0594; SMC5L1; anti-SMC5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Sequence Length
1101
Applicable Applications for anti-SMC5 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
WB: 1:500-1:5000
Immunogen
Recombinant Human Structural maintenance of chromosomes protein 5 protein (296-403AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
Western Blot (WB)
(Western BlotPositive WB detected in: HepG2 whole cell lysate, 293T whole cell lysateAll lanes: SMC5 antibody at 4.6ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 129 KDaObserved band size: 129 KDa)
Western Blot (WB)
(Western BlotPositive WB detected in: HepG2 whole cell lysate, 293T whole cell lysateAll lanes: SMC5 antibody at 4.6ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 129 KDaObserved band size: 129 KDa)
Related Product Information for anti-SMC5 antibody
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Product Categories/Family for anti-SMC5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
128,806 Da
NCBI Official Full Name
structural maintenance of chromosomes protein 5
NCBI Official Synonym Full Names
structural maintenance of chromosomes 5
NCBI Official Symbol
SMC5
NCBI Official Synonym Symbols
SMC5L1
NCBI Protein Information
structural maintenance of chromosomes protein 5
UniProt Protein Name
Structural maintenance of chromosomes protein 5
Protein Family
UniProt Gene Name
SMC5
UniProt Synonym Gene Names
KIAA0594; SMC5L1; SMC protein 5; SMC-5; hSMC5
Uniprot Description
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
Research Articles on SMC5
Similar Products
Product Notes
The SMC5 smc5 (Catalog #AAA7108375) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SMC5 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SMC5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:500-1:5000. Researchers should empirically determine the suitability of the SMC5 smc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMC5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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