Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using SMC5 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200))
Rabbit anti-Human, Mouse SMC5 Polyclonal Antibody | anti-SMC5 antibody
SMC5 Antibody
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using SMC5 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200))
Immunohistochemistry (IHC)
(The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using SMC5 Antibody at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200))
NCBI and Uniprot Product Information
Uniprot Description
SMC5: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. Belongs to the SMC family. SMC5 subfamily.
Protein type: DNA replication
Chromosomal Location of Human Ortholog: 9q21.12
Cellular Component: cell junction; chromosome, telomeric region; nucleoplasm; nucleus; PML body
Molecular Function: protein binding
Biological Process: double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; positive regulation of chromosome segregation; positive regulation of maintenance of mitotic sister chromatid cohesion; protein sumoylation; response to DNA damage stimulus; telomere maintenance via recombination
Research Articles on SMC5
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Product Notes
The SMC5 smc5 (Catalog #AAA9417056) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SMC5 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SMC5 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1: 20-100. Researchers should empirically determine the suitability of the SMC5 smc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SMC5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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