Rabbit anti-Human WDFY3 Polyclonal Antibody | anti-WDFY3 antibody

WDFY3 Antibody, HRP conjugated

Cat. Num. AAA7108372

• Gene Names: WDFY3; ALFY; BCHS; MCPH18; ZFYVE25
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G purified
• Synonyms: WDFY3; Polyclonal Antibody; WDFY3 Antibody; HRP conjugated; WD repeat and FYVE domain-containing protein 3; Autophagy-linked FYVE protein; Alfy; KIAA0993; anti-WDFY3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 3526

• Applicable Applications for anti-WDFY3 antibody: ELISA (EIA)
• Immunogen: Recombinant Human WD repeat and FYVE domain-containing protein 3 protein (1-100AA)
• Conjugation: HRP
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-WDFY3 antibody

Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.

Product Categories/Family for anti-WDFY3 antibody

Cardiovascular

NCBI and Uniprot Product Information

• NCBI GI #: 31317272
• NCBI GeneID: 23001
• NCBI Accession #: NP_055806.2
• NCBI GenBank Nucleotide #: NM_014991.4
• UniProt Accession #: Q8IZQ1; Q4W5K5; Q6P0Q5; Q8N1T2; Q8NAV6; Q96BS7; Q96D33; Q96N85; Q9Y2J7
• Molecular Weight: 393,367 Da
• NCBI Official Full Name: WD repeat and FYVE domain-containing protein 3
• NCBI Official Synonym Full Names: WD repeat and FYVE domain containing 3
• NCBI Official Symbol: WDFY3
• NCBI Official Synonym Symbols: ALFY; BCHS; MCPH18; ZFYVE25
• NCBI Protein Information: WD repeat and FYVE domain-containing protein 3
• UniProt Protein Name: WD repeat and FYVE domain-containing protein 3
• Protein Family: WD repeat and FYVE domain-containing protein
• UniProt Gene Name: WDFY3
• UniProt Synonym Gene Names: KIAA0993; Alfy

NCBI Description

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010]

Uniprot Description

Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3 (PubMed:20417604). Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:20168092). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1 (). Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development (PubMed:27008544). May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway (). After cytokinetic abscission, involved in midbody remnant degradation (PubMed:24128730). In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P) (PubMed:15292400).