Bcl-2-like protein 1 (Bcl2l1) Recombinant Protein | Bcl2l1 recombinant protein

Recombinant Mouse Bcl-2-like protein 1 (Bcl2l1) , partial

• Gene Names: Bcl2l1; BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Bcl-2-like protein 1 (Bcl2l1); Recombinant Mouse Bcl-2-like protein 1 (Bcl2l1); partial; Bcl2l1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 214

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 577019442
• NCBI GeneID: 12048
• NCBI Accession #: NP_001276645.1
• NCBI GenBank Nucleotide #: NM_001289716.1
• UniProt Accession #: Q64373; O35844; Q60657; Q60658; Q61338
• Molecular Weight: 23,900 Da
• NCBI Official Full Name: bcl-2-like protein 1 isoform a
• NCBI Official Synonym Full Names: BCL2-like 1
• NCBI Official Symbol: Bcl2l1
• NCBI Official Synonym Symbols: BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
• NCBI Protein Information: bcl-2-like protein 1
• UniProt Protein Name: Bcl-2-like protein 1
• Protein Family: Bcl-2-like protein
• UniProt Gene Name: Bcl2l1
• UniProt Synonym Gene Names: Bcl2l; Bclx; Bcl2-L-1

NCBI Description

This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]

Uniprot Description

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.