TGF-beta receptor type-2 Recombinant Protein | Tgfbr2 recombinant protein
TGF-beta receptor type-2
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
receptor for TGF-beta; may play a role in lung maturation and response to hypoxia [RGD, Feb 2006]
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; EC 2.7.11.30; Oncoprotein; TKL group; STKR family; Type2 subfamily
Cellular Component: caveola; cell surface; cytoplasm; cytosol; external side of plasma membrane; integral to membrane; integral to plasma membrane; lipid raft; plasma membrane; receptor complex
Molecular Function: glycosaminoglycan binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity
Biological Process: activation of protein kinase activity; aging; apoptosis; brain development; cartilage development; common-partner SMAD protein phosphorylation; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; gastrulation; gut development; heart development; in utero embryonic development; lens development in camera-type eye; lung development; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of cell proliferation; Notch signaling pathway; organ morphogenesis; organ regeneration; palate development; patterning of blood vessels; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of skeletal muscle regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to drug; response to estrogen stimulus; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to nutrient; response to organic cyclic substance; response to organic substance; response to steroid hormone stimulus; smoothened signaling pathway; transforming growth factor beta receptor signaling pathway; vasculogenesis; wound healing
Research Articles on Tgfbr2
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Product Notes
The Tgfbr2 tgfbr2 (Catalog #AAA7043434) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 24-567aa; full length protein. The amino acid sequence is listed below: IPPHVPKSVN SDLMAGDNSG AVKLPQLCKF CDVTLSTCDN QKSCMSNCSV TSICEKPQEV CVAVWRKNDK NITLETVCHD PKFTYHGFTL EDATSPTCVM KEKKRAGETF FMCSCNTEEC NDYIIFNEEY TTSSPDLLLV IIQVTGVSLL PPLGIAIAVI AIFYCYRVHR QQKLSPSWES SKPRKLMDFS DNCAIILEDD RSDISSTCAN NINHNTELLP IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YSSWKTEKDI FSDINLKHEN ILQFLTAEER KTEMGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR YMAPEVLESR MNLENMESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC VESMKDNVLR DRGRPEIPSF WLNHQGIQIV CETLTECWDH DPEARLTAQC VAERFSELEH PDRLSGRSCS QEKIPEDGSL NTTK. It is sometimes possible for the material contained within the vial of "TGF-beta receptor type-2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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