Western Blot (WB)
(Chemerin, also known as TIG2, is a distant member of the cystatin superfamily. The chemerin precursor is cleaved by multiple serine proteases at various sites near the C-terminus. Mature active chemerin is a 15-16kD heparin binding protein that induces immature dendritic cell and macrophage chemotaxis through interactions with ChemR23. Mature human chemerin shares 65% and 70% aa sequence identity with mouse and rat chemerin, respectively.)
Mouse anti-Human Chemerin Monoclonal Antibody | anti-CMKLR1 antibody
Chemerin (TIG2)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: Western Blot: 2ug/ml using human kidney tissue.
Optimal dilutions to be determined by the researcher.
Western Blot (WB)
(Chemerin, also known as TIG2, is a distant member of the cystatin superfamily. The chemerin precursor is cleaved by multiple serine proteases at various sites near the C-terminus. Mature active chemerin is a 15-16kD heparin binding protein that induces immature dendritic cell and macrophage chemotaxis through interactions with ChemR23. Mature human chemerin shares 65% and 70% aa sequence identity with mouse and rat chemerin, respectively.)
Western Blot (WB)
(Chemerin, also known as TIG2, is a distant member of the cystatin superfamily. The chemerin precursor is cleaved by multiple serine proteases at various sites near the C-terminus. Mature active chemerin is a 15-16kD heparin binding protein that induces immature dendritic cell and macrophage chemotaxis through interactions with ChemR23. Mature human chemerin shares 65% and 70% aa sequence identity with mouse and rat chemerin, respectively.)
NCBI and Uniprot Product Information
Uniprot Description
CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 12q24.1
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development
Research Articles on CMKLR1
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Product Notes
The CMKLR1 cmklr1 (Catalog #AAA602156) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Chemerin (TIG2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Chemerin can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Suitable for use in Western Blot and Direct ELISA. Dilution: Western Blot: 2ug/ml using human kidney tissue. Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the CMKLR1 cmklr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Chemerin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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