Tyrosine-protein phosphatase non-receptor type substrate 1 Recombinant Protein | SIRPA recombinant protein
Tyrosine-protein phosphatase non-receptor type substrate 1
Gene Names
SIRPA; MYD-1; PTPNS1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Tyrosine-protein phosphatase non-receptor type substrate 1; SIRPA recombinant protein
Host
Cell Free Expression
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Liquid containing glycerol
Sequence Positions
30-506aa; full length protein
Sequence
GDGELQVIQPERSVSVAAGETATLHCTVTSLSPVGPIKWFKGTGPGREFIYSQKEAPFPRVTNVSDATKRNNMDFSIRISNITPADAGVYYCVKFRKEERGDMEFKSGPGTHLTVSAKPSPPVLSGPTVRATPEQTVNFTCTSHGFSPRNISLKWFKNGNELSASQTSVDPEDNNVSYSINSTTKVLLATGDVHSQVICEVAHVTLQGGPPLRGTANLSETIRVPPTLEITGSPSAGNQVNVTCQVNKFYPRHLQLTWLENGNMSRTEAASVFVENKDGTFNQTSWFLVNSSAHREAVVLTCQVEHDGQPAVSKNHTLEVSAPQKDQDTGQTPGPNDSNWTSIFIVVGVVCALLVALLIAALYLLRIRQNKAKGSTSSTRLHEPEKNTRETTQIQDNNDITYADLNLPKGKKSTPKANEPNNHTEYASIQARPPPVSEDTLTYADLDMVHLNRTPKQPAPKPEPSYSEYASVQVQRK
Sequence Length
Full Length Protein
Species
Bos taurus (Bovine)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Related Product Information for SIRPA recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for SIRPA recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,093 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type substrate 1
NCBI Official Symbol
SIRPA
NCBI Official Synonym Symbols
MYD-1; PTPNS1
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type substrate 1
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type substrate 1
Protein Family
UniProt Gene Name
SIRPA
UniProt Synonym Gene Names
MYD1; PTPNS1; SHPS1; SIRP; SHP substrate 1; SHPS-1; Sirp-alpha-1
UniProt Entry Name
SHPS1_BOVIN
Uniprot Description
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells ().
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Product Notes
The SIRPA sirpa (Catalog #AAA7043329) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 30-506aa; full length protein. The amino acid sequence is listed below: GDGELQVIQP ERSVSVAAGE TATLHCTVTS LSPVGPIKWF KGTGPGREFI YSQKEAPFPR VTNVSDATKR NNMDFSIRIS NITPADAGVY YCVKFRKEER GDMEFKSGPG THLTVSAKPS PPVLSGPTVR ATPEQTVNFT CTSHGFSPRN ISLKWFKNGN ELSASQTSVD PEDNNVSYSI NSTTKVLLAT GDVHSQVICE VAHVTLQGGP PLRGTANLSE TIRVPPTLEI TGSPSAGNQV NVTCQVNKFY PRHLQLTWLE NGNMSRTEAA SVFVENKDGT FNQTSWFLVN SSAHREAVVL TCQVEHDGQP AVSKNHTLEV SAPQKDQDTG QTPGPNDSNW TSIFIVVGVV CALLVALLIA ALYLLRIRQN KAKGSTSSTR LHEPEKNTRE TTQIQDNNDI TYADLNLPKG KKSTPKANEP NNHTEYASIQ ARPPPVSEDT LTYADLDMVH LNRTPKQPAP KPEPSYSEYA SVQVQRK. It is sometimes possible for the material contained within the vial of "Tyrosine-protein phosphatase non-receptor type substrate 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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