FGF-10 active protein

Mouse FGF-10

Cat. Num. AAA692548

• Gene Names: Fgf10; AEY17; Fgf-10; BB213776; Gsfaey17
• Reactivity: Mouse
• Purity: >= 95% by SDS-PAGE gel and HPLC analyses
• Synonyms: FGF-10; Mouse FGF-10; Fibroblast Growth Factor?10; FGFA; Keratinocyte Growth Factor?2; FGF-10 active protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: >= 95% by SDS-PAGE gel and HPLC analyses
• Form/Format: Lyophilized
• Sequence: SSAGRHVRSY NHLQGDVRWR RLFSFTKYFL TIEKNGKVSG TKNEDCPYSV LEITSVEIGV VAVKAINSNY YLAMNKKGKL YGSKEFNNDC KLKERIEENG YNTYASFNWQ HNGRQMYVAL NGKGAPRRGQ KTRRKNTSAH FLPMTIQT
• Sequence Length: 148; Length [aa]

• Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.; Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week.; For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
• Endotoxin Level: < 0.1 ng/ug of protein (<1EU/ug)
• Biological Activity: Determined by dose-dependent ability to reduce tetrazolium salt, WST-8, by dehydrogenase activities of BaF3 cells expressing FGF receptors using Cell Counting Kit-8 (CCK-8).
• Preparation and Storage: The lyophilized protein is stable at room temperature for 3 weeks should be stored desiccated below -18 degree C.; Reconstituted working aliquots are stable for 1 week at 2 degree C to 8 degree C, and for 3 months at -20 degree C to -80 degree C.

Related Product Information for FGF-10 active protein

FGF-10 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-10 is most related to FGF-7/KGF, and is expressed during the development and, preferentially, in adult lungs. It signals through FGFR 2b. Recombinant Murine FGF-10 is a 17.0 kDa protein consisting of 148 amino acid residues.

NCBI and Uniprot Product Information

• NCBI GI #: 7106313
• NCBI GeneID: 14165
• NCBI Accession #: NP_032028.1
• NCBI GenBank Nucleotide #: NM_008002.4
• UniProt Accession #: O35565
• Molecular Weight: 17.0 kDa
• NCBI Official Full Name: fibroblast growth factor 10
• NCBI Official Synonym Full Names: fibroblast growth factor 10
• NCBI Official Symbol: Fgf10
• NCBI Official Synonym Symbols: AEY17; Fgf-10; BB213776; Gsfaey17
• NCBI Protein Information: fibroblast growth factor 10
• UniProt Protein Name: Fibroblast growth factor 10
• UniProt Gene Name: Fgf10
• UniProt Synonym Gene Names: FGF-10
• UniProt Entry Name: FGF10_MOUSE

Uniprot Description

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Cytokine; Secreted, signal peptide; Cell development/differentiation; Motility/polarity/chemotaxis

Cellular Component: extracellular matrix; extracellular space; cell surface; cell; extracellular region; plasma membrane; nucleus

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; fibroblast growth factor receptor binding; chemoattractant activity; receptor binding

Biological Process: salivary gland development; activation of MAPK activity; urothelial cell proliferation; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; muscle cell fate commitment; regulation of saliva secretion; embryonic pattern specification; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; positive regulation of fibroblast proliferation; epithelial cell proliferation; cell-cell signaling; positive chemotaxis; embryonic digestive tract morphogenesis; induction of an organ; embryonic gut development; embryonic genitalia morphogenesis; spleen development; positive regulation of keratinocyte migration; inner ear morphogenesis; positive regulation of DNA repair; fibroblast growth factor receptor signaling pathway; semicircular canal morphogenesis; positive regulation of urothelial cell proliferation; organ growth; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; branching morphogenesis of a tube; regulation of gene expression; blood vessel morphogenesis; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; alveolus development; positive regulation of epithelial cell proliferation; limb development; epidermis development; wound healing; radial glial cell differentiation; positive regulation of mitotic cell cycle; chemotaxis; regulation of epithelial cell proliferation; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; negative regulation of cell proliferation; establishment of mitotic spindle orientation; epithelial cell differentiation; positive regulation of MAPKKK cascade; positive regulation of lymphocyte proliferation; epidermis morphogenesis; salivary gland morphogenesis; pancreas development; positive regulation of cell proliferation; male genitalia morphogenesis; thyroid gland development; lacrimal gland development; otic vesicle formation; positive regulation of Wnt receptor signaling pathway; female genitalia morphogenesis; positive regulation of Notch signaling pathway; organ formation; hair follicle morphogenesis; thymus development; keratinocyte proliferation; regulation of activin receptor signaling pathway; limb morphogenesis; embryonic camera-type eye development; odontogenesis of dentine-containing teeth; limb bud formation; negative regulation of cell differentiation; gut development; pituitary gland development; positive regulation of ATPase activity; actin cytoskeleton reorganization; white fat cell differentiation; blood vessel remodeling; positive regulation of Ras protein signal transduction; positive regulation of DNA replication; regulation of smoothened signaling pathway; lung development