B7-H2 Fc Active Protein | B7-H2 active protein

Human B7-H2 Fc

Cat. Num. AAA692289

• Reactivity: Human
• Purity: > 95% by SDS-PAGE & HPLC analyses
• Synonyms: B7-H2 Fc; Human B7-H2 Fc; Inducible Costimulator-Ligand (ICOSL); B7 homolog 2; B7-like protein Gl50; B7-related protein 1 (B7RP-1); CD276; B7-H2 active protein

• Host: CHO cells
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & HPLC analyses
• Form/Format: Lyophilized
• Sequence: DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVT YHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE Q KFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELT FTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VV SVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENP VS TGEKNAATGG PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKD TLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQ Y NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAK GQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEA LHNHY TQKSLSLSPG K
• Sequence Length: 302

• Label: Fc-Tag
• Antigen: Recombinant Human WNT-3a
• Biological Activity: Determined by its ability to induce adhesion in Jurkat cells activated by immobilized anti-CD3. The ED50 for this effect is 0.3-0.6 ug/ml.

Related Product Information for B7-H2 active protein

of B7-H2 in immune reactions of nonlymphoid organs in which T cells have migrated to peripheral tissues having only limited expression of B7-1 and B7-2. Expression of B7-H2 has been shown to be differentially regulated by both TNF-alpha and IL-1beta, and inducible to a lesser extent by CD40 or lipopolysaccharide stimulation. B7-H2s binding to ICOS on activated T cells results in both positive and negative effects on immune response, including its own downregulation. As a member of the immunoglobulin superfamily, B7-H2 is crucially involved in inflammatory immune reactions and the control of excessive immune response; however, unlike B7-1 and B7-2, B7-H2 has not been shown to influence immunity through interaction with CTLA-4, and has only been shown to have restricted interaction with CD28. Interaction of B7-H2 with ICOS has been identified as a critical event in the immunosuppression of tumor-associated memory CD4+ T cells, and has been linked to various auto-immune disorders. Recombinant Human B7-H2 Fc is a glycosylated, disulfide-linked homodimer of 942 amino acid residues whose monomer consists of the 238-amino-acid length extracellular portion of B7-H2 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of Recombinant Human B7-H2 Fc dimer is 104.9 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 90-95 kDa by SDS-PAGE analysis under reducing conditions.

Product Categories/Family for B7-H2 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 19855066
• NCBI GeneID: 102723996
• UniProt Accession #: O75144; Q9HD18; Q9NRQ1; A8MUZ1
• Molecular Weight: 20,120 Da
• NCBI Official Full Name: ICOS ligand
• NCBI Official Symbol: LOC102723996
• NCBI Protein Information: ICOS ligand
• UniProt Protein Name: ICOS ligand
• UniProt Gene Name: ICOSLG
• UniProt Synonym Gene Names: B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1

Uniprot Description

ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: plasma membrane

Molecular Function: receptor binding

Biological Process: positive regulation of activated T cell proliferation; T cell costimulation