BMP-5 active protein
Human BMP-5
Reactivity
Human
Purity
> 95% by SDS-PAGE & HPLC analysis
Synonyms
BMP-5; Human BMP-5; BMP5; BMP-5 active protein
Host
CHO cells
Reactivity
Human
Purity/Purification
> 95% by SDS-PAGE & HPLC analysis
Form/Format
Lyophilized
Sequence
AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSF RDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV H LMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGC H
Sequence Length
454
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml.
Related Product Information for BMP-5 active protein
BMP5 belongs to the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. This superfamily is comprised of large families of growth and differentiation factors. Bone morphogenetic proteins were initially identified by their ability of demineralizing bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. BMP5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells. The BMP5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors. Human BMP-5 produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.
Product Categories/Family for BMP-5 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,670 Da
NCBI Official Full Name
bone morphogenetic protein 5 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 5
NCBI Official Symbol
BMP5
NCBI Protein Information
bone morphogenetic protein 5
UniProt Protein Name
Bone morphogenetic protein 5
UniProt Gene Name
BMP5
UniProt Synonym Gene Names
BMP-5
UniProt Entry Name
BMP5_HUMAN
Uniprot Description
BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6p12.1
Cellular Component: extracellular space; vesicle
Molecular Function: cytokine activity; transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle development; hindbrain development; negative regulation of aldosterone biosynthetic process; negative regulation of cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; neural fold elevation formation; pharyngeal system development; positive regulation of epithelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade
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Product Notes
The BMP-5 bmp5 (Catalog #AAA692244) is an Active Protein produced from CHO cells and is intended for research purposes only. The product is available for immediate purchase. The Human BMP-5 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSF RDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV H LMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGC H. It is sometimes possible for the material contained within the vial of "BMP-5, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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