MANF active protein
Human MANF
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010]
Uniprot Description
Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons
By similarity. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Ref.6 Ref.8
Subcellular location: Secreted Ref.6 Ref.8.
Induction: By endoplasmic reticulum stress. Ref.8
Domain: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. Ref.10
Post-translational modification: May contain sialic acid residues.
Sequence similarities: Belongs to the ARMET family.
Caution: Was originally (Ref.1, Ref.11 and Ref.12) thought to be much longer and included an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is now thought to be the 5'-UTR of the mRNA.It is uncertain whether Met-1 or Met-4 is the initiator.
Sequence caution: The sequence AAB08753.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAI13589.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence AAI13591.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
Research Articles on MANF
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Product Notes
The MANF manf (Catalog #AAA692051) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MANF reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGK ENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS Q ICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYI RKI NELMPKYAPK AASARTDL. It is sometimes possible for the material contained within the vial of "MANF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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