Endostatin Active Protein | COL18A1 active protein
Human Endostatin
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Description
Function: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
Subcellular location: Secreted › extracellular space › extracellular matrix
By similarity.
Tissue specificity: Present in multiple organs with highest levels in liver, lung and kidney.
Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) of the triple-helical regions are hydroxylated.
Polymorphism: There is an association between a polymorphism in position 1675 and prostate cancer. Heterozygous Asn-1675 individuals have a 2.5 times increased chance of developing prostate cancer as compared with homozygous Asp-1675 individuals.
Involvement in disease: Knobloch syndrome 1 (KNO1) [MIM:267750]: A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Ref.11
Sequence similarities: Belongs to the multiplexin collagen family.Contains 1 FZ (frizzled) domain.Contains 1 laminin G-like domain.
Research Articles on COL18A1
Similar Products
Product Notes
The COL18A1 col18a1 (Catalog #AAA692027) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Endostatin reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGT FRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG S EGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCE TWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TA SK. It is sometimes possible for the material contained within the vial of "Endostatin, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
