MIP-1 alpha active protein
Rat MIP-1 alpha
Gene Names
Ccl3; Scya3; MIP-1a
Reactivity
Rat
Purity
> 95% (SDS-PAGE; HPLC)
Synonyms
MIP-1 alpha; Rat MIP-1 alpha; Recombinant Rat MIP-1alpha; MIP-1 alpha active protein
Host
E Coli
Reactivity
Rat
Purity/Purification
> 95% (SDS-PAGE; HPLC)
Form/Format
Lyophilized
Sequence
APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRN RQIC ADPKETWVQE YITELELNA
Sequence Length
92
Endotoxin Level
< 0.1 ng/ug of MIP-1alpha
Biological Activity
Assay#1: Determined by its ability to chemoattract rat peritoneal macrophages using a concentration of 50.0-100.0 ng/ml. Assay#2: Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.
Related Product Information for MIP-1 alpha active protein
Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1alpha and MIP-1beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells. Recombinant rat MIP-1alpha is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Categories/Family for MIP-1 alpha active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
8.0 kDa
NCBI Official Full Name
C-C motif chemokine 3
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 3
NCBI Official Symbol
Ccl3
NCBI Official Synonym Symbols
Scya3; MIP-1a
NCBI Protein Information
C-C motif chemokine 3; MIP-1-alpha; small inducible cytokine A3; small-inducible cytokine A3; macrophage inflammatory protein 1-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)
UniProt Protein Name
C-C motif chemokine 3
UniProt Gene Name
Ccl3
UniProt Synonym Gene Names
Mip1a; Scya3; MIP-1-alpha
UniProt Entry Name
CCL3_RAT
NCBI Description
mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]
Uniprot Description
Function: Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regulates vascular adhesion molecules required for neutrophil influx. This protein binds heparin.
Subcellular location: Secreted.
Induction: By lipopolysaccharide (LPS).
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on MIP-1 alpha
Similar Products
Product Notes
The MIP-1 alpha ccl3 (Catalog #AAA691838) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Rat MIP-1 alpha reacts with Rat and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRN RQIC ADPKETWVQE YITELELNA. It is sometimes possible for the material contained within the vial of "MIP-1 alpha, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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