Amphiregulin (98aa) Active Protein | AREG active protein
Human Amphiregulin (98aa)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Subunit structure: The immature precursor interacts with CNIH. Ref.12
Subcellular location: Membrane; Single-pass membrane protein.
Induction: By phorbol 12-myristate 13-acetate (PMA).
Miscellaneous: AR is a protein containing cysteines in disulfide linkage(s) that are essential for its biological activity. AR may contain oligosaccharides and/or lipid moieties that are not obligatory for the biological activity.
Sequence similarities: Belongs to the amphiregulin family.Contains 1 EGF-like domain.
Research Articles on AREG
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Product Notes
The AREG areg (Catalog #AAA691722) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human Amphiregulin (98aa) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPC NAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS M IDSSLSK. It is sometimes possible for the material contained within the vial of "Amphiregulin (98aa), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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