BMP-10 active protein

Human BMP-10

Cat. Num. AAA691704

• Reactivity: Human
• Purity: >95% by SDS-PAGE & HPLC analysis
• Synonyms: BMP-10; Human BMP-10; Bone morphogenic protein 10; BMP-10 active protein

• Host: HEK 293 Cells
• Reactivity: Human
• Purity/Purification: >95% by SDS-PAGE & HPLC analysis
• Form/Format: Lyophilized
• Sequence: NAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAE HLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV V TYKFKYEGM AVSECGCR
• Sequence Length: 424

• Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 4.0-6.0 ng/ml.

Related Product Information for BMP-10 active protein

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.  It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes.  BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.  Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.

Product Categories/Family for BMP-10 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 7656928
• NCBI GeneID: 27302
• NCBI Accession #: NP_055297.1
• NCBI GenBank Nucleotide #: NM_014482.1
• UniProt Accession #: O95393; Q53R17; Q6NTE0
• Molecular Weight: 48,047 Da
• NCBI Official Full Name: bone morphogenetic protein 10 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 10
• NCBI Official Symbol: BMP10
• NCBI Protein Information: bone morphogenetic protein 10
• UniProt Protein Name: Bone morphogenetic protein 10
• UniProt Gene Name: BMP10
• UniProt Synonym Gene Names: BMP-10
• UniProt Entry Name: BMP10_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. Ref.4 Ref.5 Ref.6

Subunit structure: Homodimer; disulfide-linked

By similarity.

Subcellular location: Secreted

By similarity.

Tissue specificity: Detected in mammary epithelia (at protein level). Ref.6

Induction: Down-regulated in some breast cancer subtypes and breast cancer cell lines. Ref.6

Sequence similarities: Belongs to the TGF-beta family.