Persephin (PSP) Active Protein | PSP active protein
Mouse Persephin (PSP)
Gene Names
Pspn; PSP
Reactivity
Mouse
Purity
> 98% by SDS-PAGE
Synonyms
Persephin (PSP); Mouse Persephin (PSP); Recombinant Murine Persephin (PSP); PSP active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE
Form/Format
Lyophilized
Sequence
ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHS LVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA A CGCGG
Sequence Length
156
Endotoxin Level
< 0.1 ng per ug of Persephin
Biological Activity
The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.
Related Product Information for PSP active protein
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRalpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Product Categories/Family for PSP active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
20.6 kDa (Dimer)
NCBI Official Full Name
Persephin
NCBI Official Synonym Full Names
persephin
NCBI Official Symbol
Pspn
NCBI Official Synonym Symbols
PSP
NCBI Protein Information
persephin
UniProt Protein Name
Persephin
Protein Family
UniProt Gene Name
Pspn
UniProt Synonym Gene Names
PSP
UniProt Entry Name
PSPN_MOUSE
Uniprot Description
Function: Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
Subunit structure: Homodimer; disulfide-linked
By similarity.
Subcellular location: Secreted.
Sequence similarities: Belongs to the TGF-beta family. GDNF subfamily.
Research Articles on PSP
Similar Products
Product Notes
The PSP pspn (Catalog #AAA691632) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Persephin (PSP) reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHS LVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA A CGCGG. It is sometimes possible for the material contained within the vial of "Persephin (PSP), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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