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Flow Cytometry (FC/FACS) (Fig-1: Intracellular flow analysis of FITC conjugated hTLR8 in Jurkat cells using 0.5 ug/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents anti-FITC conjugated hTLR8 antibody.)

Mouse anti-Human TLR8/CD288 FITC Conjugated Monoclonal Antibody | anti-TLR8 antibody

Monoclonal Antibody to TLR8/CD288 FITC Conjugated (Clone: ABM15F6)

Gene Names
TLR8; CD288
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Purified
Protein G Chromatography
Synonyms
TLR8/CD288 FITC Conjugated; Monoclonal Antibody; Monoclonal Antibody to TLR8/CD288 FITC Conjugated (Clone: ABM15F6); TLR8; UNQ249/PRO286; CD288; anti-TLR8 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1 Kappa
Clone Number
ABM15F6
Purity/Purification
Purified
Protein G Chromatography
Form/Format
0.2 mg/ml in Tris buffer containing 0.05% Azide
Sequence Length
1059
Applicable Applications for anti-TLR8 antibody
Flow Cytometry (FC/FACS)
Application Notes
FC/FACS analysis: 0.5-1 ug/10^6 cells
Antigen
TLR8/CD288
Immunogen Information
A partial length recombinant TLR8 protein (amino acids 750-900) was used as the immunogen for this antibody.
Conjugation
FITC
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.

Flow Cytometry (FC/FACS)

(Fig-1: Intracellular flow analysis of FITC conjugated hTLR8 in Jurkat cells using 0.5 ug/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents anti-FITC conjugated hTLR8 antibody.)

Flow Cytometry (FC/FACS) (Fig-1: Intracellular flow analysis of FITC conjugated hTLR8 in Jurkat cells using 0.5 ug/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents anti-FITC conjugated hTLR8 antibody.)

Flow Cytometry (FC/FACS)

(Fig-2: Intracellular flow analysis of FITC conjugated hTLR8 in PBMC using 0.5 ug/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents FITC conjugated anti- hTLR8 antibody.)

Flow Cytometry (FC/FACS) (Fig-2: Intracellular flow analysis of FITC conjugated hTLR8 in PBMC using 0.5 ug/10^6 cells of FITC conjugated hTLR8 antibody (Clone: ABM15F6). Green represents isotype control; red represents FITC conjugated anti- hTLR8 antibody.)
Related Product Information for anti-TLR8 antibody
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant, termed G or A1G allele of TLR8. TLR8v1 has additional 19 amino acids in the N-terminus. It is predominantly expressed in lung and peripheral blood leukocytes.
Product Categories/Family for anti-TLR8 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
121,764 Da
NCBI Official Full Name
toll-like receptor 8 isoform 1
NCBI Official Synonym Full Names
toll like receptor 8
NCBI Official Symbol
TLR8
NCBI Official Synonym Symbols
CD288
NCBI Protein Information
toll-like receptor 8
UniProt Protein Name
Toll-like receptor 8
Protein Family
UniProt Gene Name
TLR8

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Research Articles on TLR8

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Product Notes

The TLR8 tlr8 (Catalog #AAA668954) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to TLR8/CD288 FITC Conjugated (Clone: ABM15F6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TLR8/CD288 FITC Conjugated can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS analysis: 0.5-1 ug/10^6 cells. Researchers should empirically determine the suitability of the TLR8 tlr8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR8/CD288 FITC Conjugated, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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