Western Blot (WB)
(Anti- TLR8 antibody, Western blottingAll lanes: Anti TLR8 at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 120KDObserved bind size: 120KD)
anti-Human, Rat TLR8 Polyclonal Antibody | anti-TLR8 antibody
Anti-TLR8 Antibody
Western Blot (WB)
(Anti- TLR8 antibody, Western blottingAll lanes: Anti TLR8 at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 120KDObserved bind size: 120KD)
Western Blot (WB)
(Anti- TLR8 antibody, Western blottingAll lanes: Anti TLR8 at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: HEPG2 Whole Cell Lysate at 40ugPredicted bind size: 120KDObserved bind size: 120KD)
Background: TLR8 (Toll-like receptor 8) is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288).The TLR8 gene is mapped to Xp22.3-p22.2 by Chuang and Ulevitch (2000) and Du et al. (2000). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. TLR8 recognises G-rich oligonucleotides.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Uniprot Description
TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to membrane
Molecular Function: DNA binding; double-stranded RNA binding; drug binding; receptor activity; RNA binding; single-stranded RNA binding
Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB cascade; immunoglobulin mediated immune response; inflammatory response; innate immune response; microglial cell activation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-8 biosynthetic process; regulation of cytokine secretion; regulation of protein amino acid phosphorylation; response to virus; toll-like receptor 8 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Research Articles on TLR8
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Product Notes
The TLR8 tlr8 (Catalog #AAA178184) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-TLR8 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TLR8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the TLR8 tlr8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLR8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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