SDS-Page
Toll-like receptor 8 (TLR8) Recombinant Protein | TLR8 recombinant protein
Recombinant Human Toll-like receptor 8 (TLR8) , partial
Gene Names
TLR8; CD288
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Toll-like receptor 8 (TLR8); Recombinant Human Toll-like receptor 8 (TLR8); partial; TLR8 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
27-827aa; Extracellular Domain
Sequence
EENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVT
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
SDS-Page
SDS-Page
Related Product Information for TLR8 recombinant protein
This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.
Product Categories/Family for TLR8 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
93.5 kDa
NCBI Official Full Name
toll-like receptor 8 isoform 1
NCBI Official Synonym Full Names
toll like receptor 8
NCBI Official Symbol
TLR8
NCBI Official Synonym Symbols
CD288
NCBI Protein Information
toll-like receptor 8
UniProt Protein Name
Toll-like receptor 8
Protein Family
UniProt Gene Name
TLR8
NCBI Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Uniprot Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Research Articles on TLR8
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Product Notes
The TLR8 tlr8 (Catalog #AAA1265273) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 27-827aa; Extracellular Domain. The amino acid sequence is listed below: EENFSRSYPC DEKKQNDSVI AECSNRRLQE VPQTVGKYVT ELDLSDNFIT HITNESFQGL QNLTKINLNH NPNVQHQNGN PGIQSNGLNI TDGAFLNLKN LRELLLEDNQ LPQIPSGLPE SLTELSLIQN NIYNITKEGI SRLINLKNLY LAWNCYFNKV CEKTNIEDGV FETLTNLELL SLSFNSLSHV PPKLPSSLRK LFLSNTQIKY ISEEDFKGLI NLTLLDLSGN CPRCFNAPFP CVPCDGGASI NIDRFAFQNL TQLRYLNLSS TSLRKINAAW FKNMPHLKVL DLEFNYLVGE IASGAFLTML PRLEILDLSF NYIKGSYPQH INISRNFSKL LSLRALHLRG YVFQELREDD FQPLMQLPNL STINLGINFI KQIDFKLFQN FSNLEIIYLS ENRISPLVKD TRQSYANSSS FQRHIRKRRS TDFEFDPHSN FYHFTRPLIK PQCAAYGKAL DLSLNSIFFI GPNQFENLPD IACLNLSANS NAQVLSGTEF SAIPHVKYLD LTNNRLDFDN ASALTELSDL EVLDLSYNSH YFRIAGVTHH LEFIQNFTNL KVLNLSHNNI YTLTDKYNLE SKSLVELVFS GNRLDILWND DDNRYISIFK GLKNLTRLDL SLNRLKHIPN EAFLNLPASL TELHINDNML KFFNWTLLQQ FPRLELLDLR GNKLLFLTDS LSDFTSSLRT LLLSHNRISH LPSGFLSEVS SLKHLDLSSN LLKTINKSAL ETKTTTKLSM LELHGNPFEC TCDIGDFRRW MDEHLNVKIP RLVDVICASP GDQRGKSIVS LELTTCVSDV T . It is sometimes possible for the material contained within the vial of "Toll-like receptor 8 (TLR8), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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