Flow Cytometry (FC/FACS)
(Fig-1: Cell Surface flow analysis of hCD6 in PBMC (Lymphocyte gated) using 0.5 ug/10^6 cells. Green represents isotype control ; red represents FITC conjugated anti-hCD6 antibody)
Mouse anti-Human CD6 Monoclonal Antibody | anti-CD6 antibody
Monoclonal Antibody to hCD6 (Clone: SPV14) FITC conjugated
Protein G Chromatography
Protein G Chromatography
Flow Cytometry (FC/FACS)
(Fig-1: Cell Surface flow analysis of hCD6 in PBMC (Lymphocyte gated) using 0.5 ug/10^6 cells. Green represents isotype control ; red represents FITC conjugated anti-hCD6 antibody)
Flow Cytometry (FC/FACS)
(Fig-1: Cell Surface flow analysis of hCD6 in PBMC (Lymphocyte gated) using 0.5 ug/10^6 cells. Green represents isotype control ; red represents FITC conjugated anti-hCD6 antibody)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q12.2
Cellular Component: immunological synapse; integral to plasma membrane; intrinsic to plasma membrane; T cell receptor complex
Molecular Function: lipopolysaccharide binding; protein binding
Biological Process: acute inflammatory response to antigenic stimulus; formation of immunological synapse; heterophilic cell adhesion; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; response to lipopolysaccharide
Research Articles on CD6
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Product Notes
The CD6 cd6 (Catalog #AAA668378) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Antibody to hCD6 (Clone: SPV14) FITC conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD6 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Flow Cytometry: 0.5-1 ug/10^6 cells. Researchers should empirically determine the suitability of the CD6 cd6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD6, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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