Mouse anti-Human CD11a Monoclonal Antibody | anti-CD11a antibody

Monoclonal Antibody to hCD11a (Clone: Cris3)

Cat. Num. AAA668350

• Gene Names: ITGAL; CD11A; LFA-1; LFA1A
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Purified; Protein G Chromatography
• Synonyms: CD11a; Monoclonal Antibody; Monoclonal Antibody to hCD11a (Clone: Cris3); CD11 antigen-like family member A; CD11a antigen; CD11Aantigen CD11A (p180); lymphocyte function-associated antigen 1; alphapolypeptide; ntegrin; alpha L (antigen CD11A (p180); lymphocyte function-associated antigen1; alpha polypeptide); Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; CD11A; anti-CD11a antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b Kappa
• Clone Number: Cris3
• Purity/Purification: Purified; Protein G Chromatography
• Form/Format: 25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
• Sequence Length: 1170

• Applicable Applications for anti-CD11a antibody: Flow Cytometry (FC/FACS)
• Application Notes: Flow Cytometry: 0.5-1 ug/10^6 cells
• Immunogen Information: Stimulated human leukocytes were used as immunogen for this antibody.
• Antigen: CD11a
• Preparation and Storage: Store the antibody at 4 degree C, stable for 6 months.; For long-term storage, store at -20 degree C.; Avoid repeated freeze and thaw cycles.

Flow Cytometry (FC/FACS)

(Fig-1: Cell Surface flow analysis of hCD11a in PBMC using 0.5 ug/10^6 cell. Green represents isotype control ; red represents anti-hCD11a antibody. Goat anti-mouse PE conjugated secondary antibody was used.)

Product Categories/Family for anti-CD11a antibody

Antibodies; Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 88911345
• NCBI GeneID: 3683
• UniProt Accession #: P20701; O43746; Q45H73; Q96HB1; Q9UBC8
• Molecular Weight: 119,224 Da
• NCBI Official Full Name: Integrin alpha-L
• NCBI Official Synonym Full Names: integrin subunit alpha L
• NCBI Official Symbol: ITGAL
• NCBI Official Synonym Symbols: CD11A; LFA-1; LFA1A
• NCBI Protein Information: integrin alpha-L
• UniProt Protein Name: Integrin alpha-L
• UniProt Gene Name: ITGAL
• UniProt Synonym Gene Names: CD11A; LFA-1A

NCBI Description

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; ICAM-3 receptor activity; protein binding

Biological Process: cell motility; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; leukocyte adhesion; leukocyte migration; receptor clustering; regulation of immune response; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell