Rabbit anti-Human XTP3TPA Polyclonal Antibody | anti-XTP3TPA antibody
XTP3TPA, NT (dCTP Pyrophosphatase 1, Deoxycytidine-triphosphatase 1, dCTPase 1, RS21C6, XTP3-transactivated Gene A Protein, DCTPP1, CDA03) (FITC)
ELISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of anti-XTP3TPA Antibody (N-term) in HepG2 cell line lysates (35ug/lane). XTP3TPA(arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with XTP3TPA antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Description
XTP3TPA: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.
Protein type: EC 3.6.1.12
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytosol
Molecular Function: dCTP diphosphatase activity; pyrimidine deoxyribonucleotide binding; magnesium ion binding; nucleoside-triphosphate diphosphatase activity
Biological Process: nucleoside triphosphate catabolic process; protein homotetramerization