Rabbit anti-Human TOB2 Polyclonal Antibody | anti-TOB2 antibody

TOB2, NT (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TROB2) (APC)

Cat. Num. AAA6502785

• Gene Names: TOB2; TOB4; TOBL; APRO5; TROB2
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: TOB2; Polyclonal Antibody; NT (Protein Tob2; Transducer of erbB-2 2; Protein Tob4; KIAA1663; TOB4; TROB2) (APC); anti-TOB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TOB2.
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TOB2 antibody: FLISA, Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 17-46 in the N-terminal region of human TOB2, UniProt Accession #Q14106. Species sequence homology: mouse
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HepG2 cell line lysates (35ug/lane) usingMBS630517. TOB2 (arrow) was detected usingMBS630517.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with TT7948-20A, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of tT7948-20A for immunohistochemistry.)

Related Product Information for anti-TOB2 antibody

TOB2 belongs to the TOB /BTG1 family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.

Product Categories/Family for anti-TOB2 antibody

Antibodies; Protein Kinases

References

1. Sasajima, H., Eur. J. Biochem. 269(14), 3596-3604 (2002). 2. Yoshida, Y., Jpn. J. Cancer Res. 92(6), 592-596 (2001). 3. Suzuki, T., Genes Cells 6(2), 131-138 (2001). 4. Ikematsu, N., Oncogene 18(52), 7432-7441 (1999).

NCBI and Uniprot Product Information

• NCBI GI #: 7706739
• NCBI GeneID: 10766
• NCBI Accession #: NP_057356
• NCBI GenBank Nucleotide #: NM_016272
• UniProt Accession #: Q14106
• Molecular Weight: 37kDa
• NCBI Official Full Name: protein Tob2
• NCBI Official Synonym Full Names: transducer of ERBB2, 2
• NCBI Official Symbol: TOB2
• NCBI Official Synonym Symbols: TOB4; TOBL; APRO5; TROB2
• NCBI Protein Information: protein Tob2
• UniProt Protein Name: Protein Tob2
• Protein Family: Protein
• UniProt Gene Name: TOB2
• UniProt Synonym Gene Names: KIAA1663; TOB4; TROB2

NCBI Description

TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

Uniprot Description

TOB2: Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases. Belongs to the BTG family.

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; transcription corepressor activity; vitamin D receptor binding

Biological Process: female gamete generation; negative regulation of cell proliferation; negative regulation of osteoclast differentiation; positive regulation of ossification; regulation of gene expression