Rabbit anti-Mouse, Human SIGIRR Polyclonal Antibody | anti-SIGIRR antibody
SIGIRR, CT (Single Ig IL-1-Related Receptor, Single Ig IL-1R-Related Molecule, Single Immunoglobulin Domain-Containing IL1R-Related Protein, Toll/Interleukin-1 Receptor 8, TIR8) (FITC)
IHC-F: 10ug/ml
Applications are based on unconjugated antibody.
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP
By similarity. Ref.4
Subunit structure: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3
By similarity.
Subcellular location: Membrane; Single-pass type III membrane protein
Potential.
Tissue specificity: Expressed at high levels in kidney, and at moderate levels in colon, small intestine, lung, spleen and liver. Not expressed in brain and muscle. Expressed at high levels in epithelial cells, at moderate levels in splenocytes, and at low or undetectable levels in fibroblasts or endothelial cells. Expressed in mucosal and dendritic cells. Ref.1 Ref.4 Ref.6
Induction: Down-regulated by LPS. Down-regulated during inflammation by inhibition of an SP1-mediated pathway. Ref.4 Ref.6
Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 TIR domain.
Sequence caution: The sequence AAF26200.1 differs from that shown. Reason: Frameshift at positions 244 and 275.
Research Articles on SIGIRR
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Product Notes
The SIGIRR sigirr (Catalog #AAA6499504) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIGIRR, CT (Single Ig IL-1-Related Receptor, Single Ig IL-1R-Related Molecule, Single Immunoglobulin Domain-Containing IL1R-Related Protein, Toll/Interleukin-1 Receptor 8, TIR8) (FITC) reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's SIGIRR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Frozen. WB: 0.5-1ug/ml IHC-F: 10ug/ml Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SIGIRR sigirr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIGIRR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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