Mouse anti-Human TNS4 Monoclonal Antibody | anti-TNS4 antibody

TNS4 (Tensin-4, C-terminal Tensin-like Protein, CTEN, PP14434)

Cat. Num. AAA648342

• Gene Names: TNS4; CTEN; PP14434
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: TNS4; Monoclonal Antibody; TNS4 (Tensin-4; C-terminal Tensin-like Protein; CTEN; PP14434); Anti -TNS4 (Tensin-4; anti-TNS4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 3B8
• Specificity: Recognizes human TNS4.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

• Applicable Applications for anti-TNS4 antibody: ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, ELISA and Western Blot.; Dilution: Immunofluorescence: 10ug/ml
• Immunogen: Full length recombinant corresponding to aa1-481 from human TNS4 (AAH18706) with GST tag. MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot detection against Immunogen (78.91kD).)

Western Blot (WB)

(Western Blot analysis of TNS4 expression in transfected 293T cell line by TNS4 monoclonal antibody|Lane 1: TNS4 transfected lysate (51.8kD).|Lane 2: Non-transfected lysate.)

Immunofluorescence (IF)

(Immunofluorescence of monoclonal antibody to TNS4 on HeLa cell . [antibody concentration 10ug/ml].)

Testing Data

(Detection limit for recombinant GST tagged TNS4 is ~0.1ng/ml as a capture antibody.)

Product Categories/Family for anti-TNS4 antibody

Antibodies; Abs to Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 33878245
• NCBI GeneID: 84951
• UniProt Accession #: Q8IZW8; Q71RB7; Q8WV64; Q96JV4; A6NMJ7
• Molecular Weight: 76,764 Da
• NCBI Official Full Name: TNS4 protein, partial
• NCBI Official Synonym Full Names: tensin 4
• NCBI Official Symbol: TNS4
• NCBI Official Synonym Symbols: CTEN; PP14434
• NCBI Protein Information: tensin-4; C terminal tensin like; C-terminal tensin-like protein
• UniProt Protein Name: Tensin-4
• Protein Family: Tensin
• UniProt Gene Name: TNS4
• UniProt Synonym Gene Names: CTEN
• UniProt Entry Name: TENS4_HUMAN

Uniprot Description

Function: May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton

By similarity. May promote apoptosis, via its cleavage by caspase-3.

Subunit structure: Binds to actin filaments and interacts with phosphotyrosine-containing proteins

By similarity.

Subcellular location: Cell junction › focal adhesion. Cytoplasm › cytoskeleton Ref.1.

Tissue specificity: Prostate and placenta. Down regulated in prostate cancer. Ref.1

Post-translational modification: Proteolytically cleaved by caspase-3 during apoptosis. Ref.6

Sequence similarities: Contains 1 phosphatase tensin-type domain.Contains 1 SH2 domain.

Sequence caution: The sequence AAQ15257.1 differs from that shown. Reason: Frameshift at positions 85, 296, 472 and 602.