Rabbit anti-Human Cyclin D1 Polyclonal Antibody | anti-CCND1 antibody
Cyclin D1, NT (CCND1 Protein, Cyclin D1, Isoform CRA_c, cDNA, FLJ93625, Homo Sapiens Cyclin D1 (PRAD1: Parathyroid Adenomatosis 1) (CCND1),mRNA, Cyclin D1, PRAD1: Parathyroid Adenomatosis 1, CCND1) (MaxLight 750)
FLISA: 1:1,000
Applications are based on unconjugated antibody.
NCBI and Uniprot Product Information
Uniprot Description
CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.
Protein type: Cell cycle regulation; Nuclear receptor co-regulator; Activator; Oncoprotein
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; tight junction; transcriptional repressor complex; membrane; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus; cytosol
Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; cyclin-dependent protein kinase regulator activity; protein kinase binding; transcription factor binding; transcription corepressor activity; protein kinase activity
Biological Process: fat cell differentiation; lactation; G1 DNA damage checkpoint; establishment and/or maintenance of chromatin architecture; re-entry into mitotic cell cycle; negative regulation of Wnt receptor signaling pathway; positive regulation of cyclin-dependent protein kinase activity; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; response to magnesium ion; response to vitamin E; Leydig cell differentiation; response to iron ion; response to corticosterone stimulus; response to X-ray; response to drug; Notch signaling pathway; organ regeneration; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; liver development; response to ethanol; cell division; response to estrogen stimulus; positive regulation of protein amino acid phosphorylation; mitotic cell cycle; response to calcium ion; response to DNA damage stimulus; G1/S transition of mitotic cell cycle
Disease: Von Hippel-lindau Syndrome; Myeloma, Multiple