Rabbit anti-Mouse, Rat IL17A Polyclonal Antibody | anti-IL17A antibody

IL17A Polyclonal Antibody

Cat. Num. AAA2556071

• Gene Names: Il17a; Il17; Ctla8; IL-17; Ctla-8; IL-17A
• Reactivity: Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: IL17A; Polyclonal Antibody; IL17A Polyclonal Antibody; CTLA 8; CTLA-8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8; Cytotoxic T lymphocyte associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL 17A; IL-17; IL-17A; IL17; Il17a; Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); Interleukin 17A; Interleukin-17A; Interleukin17; Interleukin17A; OTTHUMP00000016597; OTTMUSP00000046003; anti-IL17A antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
• Sequence Length: 158

• Applicable Applications for anti-IL17A antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:300-1:1000
• Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse IL-17A
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded mouse inflammatory spleen using IL17A Polyclonal Antibody at dilution of 1:300.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Rat inflammatory spleen using IL17A Polyclonal Antibody at dilution of 1:300.)

Related Product Information for anti-IL17A antibody

IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells, has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogenactivated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.

Product Categories/Family for anti-IL17A antibody

Cancer; Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 6754324
• NCBI GeneID: 16171
• NCBI Accession #: NP_034682.1
• NCBI GenBank Nucleotide #: NM_010552.3
• UniProt Accession #: Q62386; Q60971
• NCBI Official Full Name: interleukin-17A
• NCBI Official Synonym Full Names: interleukin 17A
• NCBI Official Symbol: Il17a
• NCBI Official Synonym Symbols: Il17; Ctla8; IL-17; Ctla-8; IL-17A
• NCBI Protein Information: interleukin-17A
• UniProt Protein Name: Interleukin-17A
• Protein Family: Interleukin
• UniProt Gene Name: Il17a
• UniProt Synonym Gene Names: Ctla8; Il17; IL-17; IL-17A; CTLA-8

NCBI Description

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Uniprot Description

Ligand for IL17RA (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines ().