Mouse anti-Human RASIP1 Polyclonal Antibody | anti-RASIP1 antibody

RASIP1 (Ras-interacting Protein 1, Rain)

Cat. Num. AAA646643

• Gene Names: RASIP1; RAIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: RASIP1; Polyclonal Antibody; RASIP1 (Ras-interacting Protein 1; Rain); Anti -RASIP1 (Ras-interacting Protein 1; anti-RASIP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RASIP1.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLDSNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWSRAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRGPPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVATSP

• Applicable Applications for anti-RASIP1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human RASIP1, aa1-317 (AAH21860.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of RASIP1 expression in transfected 293T cell line by RASIP1 polyclonal antibody. Lane1:RASIP1 transfected lysate (34.87kD). Lane2:Non-transfected lysate.)

Product Categories/Family for anti-RASIP1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 27469793
• NCBI GeneID: 54922
• UniProt Accession #: Q5U651; Q6U676
• Molecular Weight: 103,457 Da
• NCBI Official Full Name: RASIP1 protein, partial
• NCBI Official Synonym Full Names: Ras interacting protein 1
• NCBI Official Symbol: RASIP1
• NCBI Official Synonym Symbols: RAIN
• NCBI Protein Information: ras-interacting protein 1
• UniProt Protein Name: Ras-interacting protein 1
• Protein Family: Ras-interacting protein
• UniProt Gene Name: RASIP1
• UniProt Synonym Gene Names: Rain
• UniProt Entry Name: RAIN_HUMAN

Uniprot Description

Function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells

By similarity. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. Ref.1 Ref.3

Subunit structure: Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29

By similarity. Ref.1

Subcellular location: Cytoplasm › perinuclear region. Golgi apparatus › Golgi stack. Note: Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS. Ref.1

Tissue specificity: Highly expressed in heart. Detected at lower levels in placenta and pancreas. Ref.1

Sequence similarities: Contains 1 dilute domain.Contains 1 Ras-associating domain.