Cat Glomerular Basement Membrane Antibody ELISA Kit | GBM elisa kit
Cat Glomerular Basement Membrane Antibody ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
Uniprot Description
GCLM: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008]
Protein type: Other Amino Acids Metabolism - glutathione
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: glutamate-cysteine ligase complex; cytosol
Molecular Function: protein heterodimerization activity; glutamate-cysteine ligase activity; enzyme regulator activity; glutamate-cysteine ligase catalytic subunit binding
Biological Process: response to drug; response to nitrosative stress; glutamate metabolic process; apoptotic mitochondrial changes; cysteine metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process; glutathione biosynthetic process; negative regulation of neuron apoptosis; response to oxidative stress; regulation of mitochondrial depolarization; regulation of blood vessel size; positive regulation of glutamate-cysteine ligase activity
Disease: Myocardial Infarction, Susceptibility To