Rabbit anti-Human IMPA2 Polyclonal Antibody | anti-IMPA2 antibody

IMPA2 (Inositol monophosphatase 2, IMP 2, IMPase 2, Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2, IMPA2, IMP18P) (FITC)

Cat. Num. AAA6456660

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IMPA2; Polyclonal Antibody; IMPA2 (Inositol monophosphatase 2; IMP 2; IMPase 2; Inositol-1(or 4)-monophosphatase 2; Myo-inositol monophosphatase A2; IMP18P) (FITC); anti-IMPA2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IMPA2. Species Crossreactivity: human
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-IMPA2 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa48-82 from human IMPA2.
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-IMPA2 antibody

Antibodies; Enzymes; Phosphatase

References

Yoshikawa T., et al. Mol. Psychiatry 2:393-397(1997). Sjoeholt G., et al. Mol. Psychiatry 5:172-180(2000). Parthasarathy L., et al. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases. Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. Mural R.J., et al. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

• NCBI GI #: 7657236
• NCBI GeneID: 3613
• NCBI Accession #: NP_055029.1
• NCBI GenBank Nucleotide #: NM_014214.2
• UniProt Accession #: O14732; Q9UJT3; B0YJ29
• Molecular Weight: 28,512 Da
• NCBI Official Full Name: inositol monophosphatase 2
• NCBI Official Synonym Full Names: inositol(myo)-1(or 4)-monophosphatase 2
• NCBI Official Symbol: IMPA2
• NCBI Protein Information: inositol monophosphatase 2; IMP 2; IMPase 2; inosine monophosphatase 2; inositol monophosphatase 2 variant 1; inositol monophosphatase 2 variant 2; myo-inositol monophosphatase A2
• UniProt Protein Name: Inositol monophosphatase 2
• UniProt Gene Name: IMPA2
• UniProt Synonym Gene Names: IMP.18P; IMP 2; IMPase 2
• UniProt Entry Name: IMPA2_HUMAN

NCBI Description

This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

Uniprot Description

IMPA2: Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain. Belongs to the inositol monophosphatase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; Phosphatase (non-protein); Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18p11.2

Cellular Component: cytoplasm; cytosol

Molecular Function: protein homodimerization activity; metal ion binding; inositol-1(or 4)-monophosphatase activity

Biological Process: inositol phosphate metabolic process; phosphoinositide phosphorylation; inositol biosynthetic process; inositol phosphate dephosphorylation; signal transduction; phosphate metabolic process