Rabbit anti-Human PNN Polyclonal Antibody | anti-PNN antibody

PNN (DRS, MEMA, Pinin, 140kD Nuclear and Cell Adhesion-related Phosphoprotein, Desmosome-associated Protein, Domain-rich Serine Protein, Melanoma Metastasis Clone A Protein, Nuclear Protein SDK3, SR-like Protein) (MaxLight 405)

Cat. Num. AAA6389993

• Gene Names: PNN; DRS; DRSP; SDK3; memA
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PNN; Polyclonal Antibody; PNN (DRS; MEMA; Pinin; 140kD Nuclear and Cell Adhesion-related Phosphoprotein; Desmosome-associated Protein; Domain-rich Serine Protein; Melanoma Metastasis Clone A Protein; Nuclear Protein SDK3; SR-like Protein) (MaxLight 405); anti-PNN antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PNN.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-PNN antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PNN, aa1-717 (NP_002678.2).
• Immunogen Sequence: MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-PNN antibody

Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.

Product Categories/Family for anti-PNN antibody

Antibodies; Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 33356174
• NCBI GeneID: 5411
• NCBI Accession #: NP_002678.2
• NCBI GenBank Nucleotide #: NM_002687.2
• UniProt Accession #: Q9H307; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9UHZ9; Q9UQR9; B4DZX8
• Molecular Weight: 81,614 Da
• NCBI Official Full Name: pinin
• NCBI Official Synonym Full Names: pinin, desmosome associated protein
• NCBI Official Symbol: PNN
• NCBI Official Synonym Symbols: DRS; DRSP; SDK3; memA
• NCBI Protein Information: pinin; SR-like protein; neutrophil protein; nuclear protein SDK3; domain-rich serine protein; desmosome-associated protein; melanoma metastasis clone A protein; 140 kDa nuclear and cell adhesion-related phosphoprotein
• UniProt Protein Name: Pinin
• Protein Family: Pinin
• UniProt Gene Name: PNN
• UniProt Synonym Gene Names: DRS; MEMA; DRS protein; DRSP
• UniProt Entry Name: PININ_HUMAN

Uniprot Description

PNN: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma. Belongs to the pinin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Spliceosome; RNA-binding; RNA splicing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 14q21.1

Cellular Component: nucleoplasm; desmosome; membrane; cytoplasm; plasma membrane; intermediate filament; nuclear speck; intercellular junction

Molecular Function: DNA binding; structural molecule activity

Biological Process: nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cell adhesion