FCRLB Active Protein | FCRLA active protein
FCRLB, Recombinant, Human (FCRL2, FCRY, FREB2, Fc Receptor-like B, Fc Receptor homolog expressed in B cells Protein 2, Fc Receptor-like and Mucin-like Protein 2, Fc Receptor-like Protein 2, Fc Receptor-related Protein Y, FCRLM2, FCRLY, FcRY, FLJ31052, FRE
Gene Names
FCRLA; FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2; RP11-474I16.5
Purity
Purified90% (SDS-PAGE)
Synonyms
FCRLB; Recombinant; Human (FCRL2; FCRY; FREB2; Fc Receptor-like B; Fc Receptor homolog expressed in B cells Protein 2; Fc Receptor-like and Mucin-like Protein 2; Fc Receptor-like Protein 2; Fc Receptor-related Protein Y; FCRLM2; FCRLY; FcRY; FLJ31052; FRE; FCRLA active protein
Purity/Purification
Purified
90% (SDS-PAGE)
90% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from PBS, EDTA. Carrier free. Reconstitute with 100ug/ml PBS.
Biological Activity
Measured by the ability to bind human IgG with an estimated KD <120nM.
Endotoxin Level
1EU/ug (LAL)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Reconstitute with 100ug/ml PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for FCRLA active protein
FCRLB, also known as FCRL2, FCRY, and FREB2, is a 60kD protein with sequence homology to classical Fc receptors. There are at least six type 1 transmembrane FCRL proteins and two that lack transmembrane segments. Each family member contains between three and nine immunoglobulin-like domains. FCRL proteins are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation. According to our testing, FCRLB binds to purified human IgG with high affinity. Human FCRLB shares 82% and 85% aa sequence identity with mouse and rat FCRLB, respectively. It contains a putative signal peptide, three immunoglobulin-like domains, and a mucin-like stalk that is rich in Pro, Ser, and Thr residues. The stalk region also contains di-Leu motifs and an unpaired cysteine. Alternative splicing generates isoforms with deletions in the putative signal peptide and substitutions and/or truncations in the third Ig -like domain. When expressed in transfectants, FCRLB is not secreted but shows a diffuse intracellular localization. FCRLB is expressed at a low level in placenta and in B lineage cells of the germinal center. It is upregulated in B cells by BAFF and LPS. Among non-hematopoietic cells, FCRLB is expressed in fibroblasts, melanocytes, and melanoma. It is preferentially expressed in nonproliferating cells and at the onset of apoptosis.
Product Categories/Family for FCRLA active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
65-70kD
NCBI Official Full Name
Fc receptor-like A isoform 3
NCBI Official Synonym Full Names
Fc receptor-like A
NCBI Official Symbol
FCRLA
NCBI Official Synonym Symbols
FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2; RP11-474I16.5
NCBI Protein Information
Fc receptor-like A; fc receptor-like protein; Fc receptor related protein X; fc receptor-related protein X; Fc receptor-like and mucin-like 1; fc receptor homolog expressed in B-cells; fc receptor-like and mucin-like protein 1; Fc receptor homolog expressed in B cells (FREB)
UniProt Protein Name
Fc receptor-like A
Protein Family
UniProt Gene Name
FCRLA
UniProt Synonym Gene Names
FCRL; FCRL1; FCRLM1; FCRX; FREB; FcRX
UniProt Entry Name
FCRLA_HUMAN
NCBI Description
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
FCRLA iso9: May be implicated in B-cell differentiation and lymphomagenesis. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component: cytoplasm; extracellular region
Biological Process: cell differentiation
Research Articles on FCRLA
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Product Notes
The FCRLA fcrla (Catalog #AAA638239) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FCRLB, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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