CD29 Active Protein | ITGB1 active protein
CD29, Recombinant, Human (Integrin alpha 10 beta 1, Integrin, beta1, CD29, Very Late Antigen, VLAb1, Platelet gplla, ITGB1, Fibrinogen Receptor beta Subunit, FNRB, Integrin VLA4 Subunit beta, MDF2, MSK12, Very Late Activation Protein beta Polypeptide, VLA
Gene Names
ITGB1; CD29
Purity
Purified95% (SDS-PAGE)
Synonyms
CD29; Recombinant; Human (Integrin alpha 10 beta 1; Integrin; beta1; Very Late Antigen; VLAb1; Platelet gplla; ITGB1; Fibrinogen Receptor beta Subunit; FNRB; Integrin VLA4 Subunit beta; MDF2; MSK12; Very Late Activation Protein beta Polypeptide; VLA; ITGB1 active protein
Purity/Purification
Purified
95% (SDS-PAGE)
95% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from PBS. Carrier free. Reconstitute with 200ug/ml PBS.
Biological Activity
Measured by its binding ability in a functional ELISA. When mouse Laminin is coated at 10ug/ml, Integrin a10b1 binds with an apparant Kd<5nM.
Endotoxin Level
1EU/ug (LAL)
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Reconstitute with 200ug/ml PBS. Aliquot and store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for ITGB1 active protein
Integrin a10b1 is one of twelve integrin family adhesion receptors that share the b1 subunit. The non-covalent heterodimer of 160kD a11 and 130kD b1/CD29 type I transmembrane glycoprotein subunits is expressed mainly on chondrocytes within cartilage, but also infibrous connective tissues such as heart valves and ligaments. The a10 extracellular domain (ECD) contains an I (inserted) domain which includes the ligand binding site. The b1 ECD contains a vWFA domain, which participates in binding. Each subunit then has a transmembrane sequence and a short cytoplasmic tail. The dimer is folded when it is least active. Divalent cations and intracellular (inside-out) signaling convert it to its most active, extended and open conformation. The 1100aa human a10 extracellular domain (ECD) shares 88-92% aa sequence identity with mouse, rat, canine and bovine a10, while the 708aa human b1 ECD shares 92-96% aa sequence identity with rat, bovine, mouse, and feline b1. A reported a10 splice variant lacking ECD aa974-1012 was not expressed on the cell surface. I domain-containing b1 integrins a1b1, a2b2, a10b1 and a11b1 all bind collagens; all but a11b1 also bind laminins. During cartilage differentiation, a10b1 is thought to be the main integrin binding type II and IX cartilage collagens. However, deletion of mouse a10 causes a mild phenotype including slightly shortened bones and narrowed hypertrophic zones, indicating that another collagen-binding integrin, likely a2b1, may compensate for a10b1 functions. Migration of melanoma cells has been noted to correlate with a10b1 expression.
Product Categories/Family for ITGB1 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
160-175kD, 125-150kD
NCBI Official Full Name
CD29
NCBI Official Symbol
ITGB1
NCBI Official Synonym Symbols
CD29
NCBI Protein Information
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); integrin beta 1
Protein Family
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Product Notes
The ITGB1 (Catalog #AAA637992) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CD29, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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