CTRP5 Recombinant Protein | C1QTNF5 recombinant protein

CTRP5, Recombinant, Human (His) (Complement C1q Tumor Necrosis Factor-related Protein 5, C1QTNF5)

Cat. Num. AAA636155

• Gene Names: C1QTNF5; CTRP5
• Purity: >90%
• Synonyms: CTRP5; Recombinant; Human (His) (Complement C1q Tumor Necrosis Factor-related Protein 5; C1QTNF5); C1QTNF5 recombinant protein

• Host: Human, E Coli
• Purity/Purification: >90%
• Form/Format: Supplied as a lyophilized powder from a 0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, 150mM NaCl. Recontitute with sterile dH2O
• Sequence: Human CTRP5 (aa 16-243) is fused at the N-terminus to a His-tag.

• Endotoxin: <1EU/ug
• Preparation and Storage: Lyopholized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute, aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 3 months. For maximum recovery of product centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for C1QTNF5 recombinant protein

CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
Recombinant protein corresponding to full length human CTRP5 (aa16-243), fused to His-tag at N-terminal, expressed in E.coli

Product Categories/Family for C1QTNF5 recombinant protein

Growth Factors; Cytokines; Growth Factors-TNF

NCBI and Uniprot Product Information

• NCBI GI #: 510025462
• NCBI GeneID: 114902
• NCBI Accession #: NP_001265360.1
• NCBI GenBank Nucleotide #: NM_001278431.1
• UniProt Accession #: Q9BXJ0; Q335M2; Q8N6P2; Q9UFX4; A6NDD3; B0YJ35
• Molecular Weight: ~26kD (SDS-PAGE)
• NCBI Official Full Name: complement C1q tumor necrosis factor-related protein 5
• NCBI Official Synonym Full Names: C1q and tumor necrosis factor related protein 5
• NCBI Official Symbol: C1QTNF5
• NCBI Official Synonym Symbols: CTRP5
• NCBI Protein Information: complement C1q tumor necrosis factor-related protein 5; myonectin; C1q TNF-alpha-related protein 5
• UniProt Protein Name: Complement C1q tumor necrosis factor-related protein 5
• Protein Family: Complement C1q tumor necrosis factor-related protein
• UniProt Gene Name: C1QTNF5
• UniProt Synonym Gene Names: CTRP5
• UniProt Entry Name: C1QT5_HUMAN

NCBI Description

This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]

Uniprot Description

C1QTNF5: Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD). LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: collagen

Disease: Late-onset Retinal Degeneration